ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate

Base Information

Chemical Name:ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate
CAS No.:628334-51-0
Molecular Formula:C₂₅H₂₈F₃N₃O₅
Molecular Weight:507.51
Hs Code.:

Synonyms:ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate

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Chemical Property of ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate

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Technology Process of ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate

There total 13 articles about ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 628334-57-6
ethyl 3-[3-benzyloxy-4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)phenyl]propanoate

: 628334-51-0
ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; at 20 ℃;

Reference yield: 75.0%

: 2-[3-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)phenyl]-2-methylpropanoic acid

: 628334-51-0
ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate

Guidance literature:: 2-[3-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)phenyl]-2-methylpropanoic acid; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 628334-51-0
ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 100 °C

1.2: 1 h / 0 - 20 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran; ethanol / 20 °C

With tributylphosphine; hydrogen; potassium carbonate; 1,1'-azodicarbonyl-dipiperidine; 5%-palladium/activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol;