Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester
• CAS No.: 86979-49-9
• Molecular Formula: C₆₃H₅₈ClN₆O₁₀P
• Molecular Weight: 1125.61
• Mol file: 86979-49-9.mol

Synonyms:Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Chemical Property of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

There total 5 articles about Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) + (chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium (86979-44-4) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (86979-49-9)

Guidance literature:

With 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In pyridine; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(00)88013-2

Reference yield:

4-tritylphenol (978-86-9) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (86979-49-9)

Guidance literature:

Multi-step reaction with 5 steps

1: N-chloroacetamide/HCl / H₂O; dioxane

2: POCl₃,ethyl-1 methyl-2 chloro-5 imidazole

3: pyridine

4: 65 percent / pyridine / 1 h / Ambient temperature

5: 67 percent / mesitylsulfonyl-1 nitro-3 triazole-1,2,4 / pyridine / 1 h / Ambient temperature

With pyridine; hydrogenchloride; N-chloroacetamide; POCl₃,ethyl-1 methyl-2 chloro-5 imidazole; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; trichlorophosphate; In 1,4-dioxane; pyridine; water;

DOI:10.1016/S0040-4039(00)88013-2

Reference yield:

2-chloro-4-trityl-phenol (859820-69-2) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (86979-49-9)

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃,ethyl-1 methyl-2 chloro-5 imidazole

2: pyridine

3: 65 percent / pyridine / 1 h / Ambient temperature

4: 67 percent / mesitylsulfonyl-1 nitro-3 triazole-1,2,4 / pyridine / 1 h / Ambient temperature

With pyridine; POCl₃,ethyl-1 methyl-2 chloro-5 imidazole; 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; trichlorophosphate; In pyridine;

DOI:10.1016/S0040-4039(00)88013-2

upstream raw materials:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

(chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium

4-tritylphenol

2-chloro-4-trityl-phenol