(chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium

Base Information

• Chemical Name: (chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium
• CAS No.: 86979-44-4
• Molecular Formula: C₆H₁₅N*C₂₈H₂₃ClNO₄P
• Molecular Weight: 605.113
• Mol file: 86979-44-4.mol

Synonyms:(chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium

Chemical Property of (chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium

There total 4 articles about (chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Phosphoric acid 2-chloro-4-trityl-phenyl ester bis-(2-cyano-ethyl) ester (86979-42-2) + triethylamine (121-44-8) → Phosphoric acid mono-(2-chloro-4-trityl-phenyl) ester; compound with triethyl-amine (86979-46-6) + (chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium (86979-44-4)

Guidance literature:

In pyridine; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(00)88013-2

Reference yield:

4-tritylphenol (978-86-9) → (chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium (86979-44-4)

Guidance literature:

Multi-step reaction with 4 steps

1: N-chloroacetamide/HCl / H₂O; dioxane

2: POCl₃,ethyl-1 methyl-2 chloro-5 imidazole

3: pyridine

4: 65 percent / pyridine / 1 h / Ambient temperature

With pyridine; hydrogenchloride; N-chloroacetamide; POCl₃,ethyl-1 methyl-2 chloro-5 imidazole; trichlorophosphate; In 1,4-dioxane; pyridine; water;

DOI:10.1016/S0040-4039(00)88013-2

Reference yield:

2-chloro-4-trityl-phenol (859820-69-2) → (chloro-2 trityl-4 phenyl)β-cyanoethyl phosphate de triethylammonium (86979-44-4)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃,ethyl-1 methyl-2 chloro-5 imidazole

2: pyridine

3: 65 percent / pyridine / 1 h / Ambient temperature

With pyridine; POCl₃,ethyl-1 methyl-2 chloro-5 imidazole; trichlorophosphate; In pyridine;

DOI:10.1016/S0040-4039(00)88013-2

upstream raw materials:

Phosphoric acid 2-chloro-4-trityl-phenyl ester bis-(2-cyano-ethyl) ester

triethylamine

4-tritylphenol

2-chloro-4-trityl-phenol

Downstream raw materials:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester

Phosphoric acid 2-chloro-4-trityl-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester