(2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Base Information

Chemical Name:(2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide
CAS No.:1581704-51-9
Molecular Formula:C₃₁H₃₅F₆N₅O₄
Molecular Weight:655.64
Hs Code.:

(2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Synonyms:(2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

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Chemical Property of (2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

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Technology Process of (2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

There total 12 articles about (2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 40499-83-0
pyrrolidin-3-ol

: 1401066-79-2
(2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3- trifluoropropyl)succinamide

: 1581704-51-9
(2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Guidance literature:: With formaldehyd; In methanol; at 75 ℃; for 18h;

Reference yield:

: 1401067-03-5
(2R,3S)-3-(tert-butoxycarbonyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

: 1581704-51-9
(2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere

1.2: 20 - 25 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / Inert atmosphere

4.1: formaldehyd / methanol / 18 h / 75 °C

With formaldehyd; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1401067-01-3
tert-butyl (3R)-6,6,6-trifluoro-3-(((4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-2-(3,3,3-trifluoropropyl)hexanoate

: 1581704-51-9
(2S,3R)-N-((3-hydroxy-1-pyrrolidinyl)methyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dihydrogen peroxide; lithium hydroxide / water; tetrahydrofuran / 1 h / 0 °C

2.1: N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere

2.2: 20 - 25 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / Inert atmosphere

5.1: formaldehyd / methanol / 18 h / 75 °C

With formaldehyd; dihydrogen peroxide; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;