1401066-79-2 Usage
General Description
BMS-906024 is a potent and selective Notch inhibitor that has shown promising antitumor activity in preclinical studies. It targets the Notch signaling pathway, which plays a critical role in cell survival, proliferation, and differentiation. By inhibiting Notch, BMS-906024 has been shown to induce cell cycle arrest and apoptosis in various cancer cell lines, including those resistant to chemotherapy. In addition, it has demonstrated the ability to suppress tumor growth and metastasis in animal models. These findings suggest that BMS-906024 may have potential as a therapeutic agent for the treatment of various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1401066-79-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,1,0,6 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1401066-79:
(9*1)+(8*4)+(7*0)+(6*1)+(5*0)+(4*6)+(3*6)+(2*7)+(1*9)=112
112 % 10 = 2
So 1401066-79-2 is a valid CAS Registry Number.
1401066-79-2Relevant articles and documents
A Practical Approach for Enantio- and Diastereocontrol in the Synthesis of 2,3-Disubstituted Succinic Acid Esters: Synthesis of the pan-Notch Inhibitor BMS-906024
Quesnelle, Claude A.,Gill, Patrice,Kim, Soong-Hoon,Chen, Libing,Zhao, Yufen,Fink, Brian E.,Saulnier, Mark,Frennesson, David,DeMartino, Michael P.,Baran, Phil S.,Gavai, Ashvinikumar V.
, p. 2254 - 2258 (2016/10/19)
An oxidative intermolecular enolate heterocoupling reaction was employed for the synthesis of anti-2,3-disubstituted succinic acid mono- and differentially protected diesters. Tactical approaches to access all the diastereomers are discussed. The method w
PRODRUGS OF 1,4-BENZODIAZEPINONE COMPOUNDS
-
, (2014/04/04)
Disclosed are compounds of Formula (I) and salts thereof, wherein: a) R1 is H or CH3, and R2 is Ry; or b) R1 is Rx and R2 is H; wherein Rx and Ry are disclosed herein.