N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-phenylacetamide

Base Information

Chemical Name:N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-phenylacetamide
CAS No.:1000334-19-9
Molecular Formula:C₂₁H₂₄N₂O₃
Molecular Weight:352.433
Hs Code.:

Synonyms:N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-phenylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-phenylacetamide

Chemical Property:

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Technology Process of N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-phenylacetamide

There total 14 articles about N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1000334-09-7
N-[2-(6-amino-7-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]acetamide hydrochloride

: 103-80-0
phenylacetyl chloride

: 1000334-19-9
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-phenylacetamide

Guidance literature:: With pyridine; at 0 ℃; for 0.25h;

Reference yield:

: 90792-61-3
4-bromo-7-hydroxy-6-nitroindan-1-one

: 1000334-19-9
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 40 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 0.5 h

3.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

4.1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

7.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

8.1: pyridine / 0.25 h / 0 °C

With pyridine; ammonia; hydrogen; boron tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; cobalt; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1000334-03-1
4-bromo-7-methoxy-6-nitroindan-1-one

: 1000334-19-9
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 0.5 h

2.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

3.1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

6.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

7.1: pyridine / 0.25 h / 0 °C

With pyridine; ammonia; hydrogen; boron tribromide; sodium hydride; triethylamine; palladium 10% on activated carbon; cobalt; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;