(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

Base Information

Chemical Name:(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one
CAS No.:700370-32-7
Molecular Formula:C₁₉H₁₆FN₉O₂
Molecular Weight:421.394
Hs Code.:

Synonyms:(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

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Chemical Property of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

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Technology Process of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

There total 10 articles about (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 288-36-8
1,2,3-triazole

: 856867-59-9
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one

: 700370-32-7
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

: (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-2-yl)methyloxazolidin-2-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.01.014

Reference yield:

: 97483-77-7
2-Cyano-5-bromopyridine

: 700370-32-7
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide; ammonium chloride / DMF (N,N-dimethyl-formamide) / 1 h / 120 °C

2.1: sodium hydroxide / DMF (N,N-dimethyl-formamide)

2.2: 2 h / 0 - 20 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1.5 h / 80 °C

With sodium hydroxide; sodium azide; potassium carbonate; ammonium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); water;

Reference yield:

: 149524-42-5
(5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one

: 700370-32-7
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: dmap; triethylamine / dichloromethane / 18.5 h / 20 °C

2: iodine; silver trifluoroacetate / chloroform; acetonitrile / 36.5 h / 20 °C

3: methanol; potassium carbonate / dichloromethane / 0.42 h / 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C

5: sodium azide / DMF (N,N-dimethyl-formamide) / 75 °C

6: 1,4-dioxane / 100 °C

7: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 1.5 h / 80 °C

8: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1.5 h / 80 °C

With methanol; dmap; sodium azide; iodine; potassium acetate; silver trifluoroacetate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dichloromethane; chloroform; water; dimethyl sulfoxide; acetonitrile;