(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one

Base Information

Chemical Name:(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one
CAS No.:856867-59-9
Molecular Formula:C₁₈H₁₇FN₆O₅S
Molecular Weight:448.435
Hs Code.:

Synonyms:(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one

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Chemical Property of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one

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Technology Process of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one

There total 5 articles about (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 856866-72-3
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one

: 124-63-0
methanesulfonyl chloride

: 856867-59-9
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 856867-59-9
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanide / N,N-dimethyl-formamide / 7 h / 150 °C / Inert atmosphere

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere

3: sodium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

5: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium cyanide; bis-triphenylphosphine-palladium(II) chloride; sodium azide; ammonium chloride; triethylamine; lithium chloride; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; 4: Stille coupling;
DOI:10.1016/j.ejmech.2011.01.014

Reference yield:

: 97483-77-7
2-Cyano-5-bromopyridine

: 856867-59-9
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere

2: sodium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium azide; ammonium chloride; triethylamine; lithium chloride; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; 3: Stille coupling;
DOI:10.1016/j.ejmech.2011.01.014