1-benzyl-6,7-dimethoxy-3-etoxycarbonylmethyl-4-(2-trimethylsilylethoxy)carbonylaminoindole

Base Information

Chemical Name:1-benzyl-6,7-dimethoxy-3-etoxycarbonylmethyl-4-(2-trimethylsilylethoxy)carbonylaminoindole
CAS No.:137043-26-6
Molecular Formula:C₂₇H₃₆N₂O₆Si
Molecular Weight:512.678
Hs Code.:

Synonyms:1-benzyl-6,7-dimethoxy-3-etoxycarbonylmethyl-4-(2-trimethylsilylethoxy)carbonylaminoindole

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Chemical Property of 1-benzyl-6,7-dimethoxy-3-etoxycarbonylmethyl-4-(2-trimethylsilylethoxy)carbonylaminoindole

Chemical Property:

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Technology Process of 1-benzyl-6,7-dimethoxy-3-etoxycarbonylmethyl-4-(2-trimethylsilylethoxy)carbonylaminoindole

There total 12 articles about 1-benzyl-6,7-dimethoxy-3-etoxycarbonylmethyl-4-(2-trimethylsilylethoxy)carbonylaminoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 638-07-3
ethyl (2-chloroaceto)acetate

: 137022-85-6
1-benzylamino-2,3-dimethoxy-5-(2-trimethylsilylethoxy)carbonylaminobenzene

: 137043-26-6
1-benzyl-6,7-dimethoxy-3-etoxycarbonylmethyl-4-(2-trimethylsilylethoxy)carbonylaminoindole

Guidance literature:: In ethanol; Heating;
DOI:10.1016/S0040-4039(00)79889-3

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 137043-26-6
1-benzyl-6,7-dimethoxy-3-etoxycarbonylmethyl-4-(2-trimethylsilylethoxy)carbonylaminoindole

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 2 h / 60 °C

2: 100 percent / hydrogen / 10percent Pd-C / ethanol / 2 h

3: acetonitrile / 1 h

4: NaBH₃CN / acetonitrile / 12 h / 50 °C

5: 85 percent / molecular sieves 3 Angstroem / ethanol / 72 h / Heating

With 3 A molecular sieve; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In ethanol; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)85065-1

Reference yield:

: 22027-96-9
5-nitroveratral

: 137043-26-6
1-benzyl-6,7-dimethoxy-3-etoxycarbonylmethyl-4-(2-trimethylsilylethoxy)carbonylaminoindole

Guidance literature:: Multi-step reaction with 11 steps

1: iron dust, 12 M HCl / methanol / 10 h / Heating

2: Na₂CO₃ / diethyl ether; H₂O / 1.) 0 deg C, 30 min; 2.) room temp., 2 h

3: 93 percent / Jones reagent / acetone / 1.) 0 deg C, 30 min; 2.) room temp., 1 h

4: tetrahydrofuran / 2 h / Ambient temperature

5: 2 M aq. NaN₃ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

6: toluene / 0.5 h / Heating

7: toluene / 2 h / 60 °C

8: 100 percent / hydrogen / 10percent Pd-C / ethanol / 2 h

9: acetonitrile / 1 h

10: NaBH₃CN / acetonitrile / 12 h / 50 °C

11: 85 percent / molecular sieves 3 Angstroem / ethanol / 72 h / Heating

With hydrogenchloride; sodium azide; jones reagent; 3 A molecular sieve; hydrogen; iron; sodium cyanoborohydride; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)85065-1