Acetamide, 2-chloro-N-(2,3-dihydroxypropyl)-N-(phenylmethyl)-, (S)-

Base Information

Chemical Name:Acetamide, 2-chloro-N-(2,3-dihydroxypropyl)-N-(phenylmethyl)-, (S)-
CAS No.:135065-72-4
Molecular Formula:C₁₂H₁₆ClNO₃
Molecular Weight:257.717
Hs Code.:
DSSTox Substance ID:DTXSID001162815

Synonyms:SCHEMBL9209218;DTXSID001162815;Acetamide, 2-chloro-N-(2,3-dihydroxypropyl)-N-(phenylmethyl)-, (S)-;135065-72-4

Suppliers and Price of Acetamide, 2-chloro-N-(2,3-dihydroxypropyl)-N-(phenylmethyl)-, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetamide, 2-chloro-N-(2,3-dihydroxypropyl)-N-(phenylmethyl)-, (S)-

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:257.0818711
Heavy Atom Count:17
Complexity:232

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CN(CC(CO)O)C(=O)CCl
Isomeric SMILES:C1=CC=C(C=C1)CN(C[C@@H](CO)O)C(=O)CCl

Technology Process of Acetamide, 2-chloro-N-(2,3-dihydroxypropyl)-N-(phenylmethyl)-, (S)-

There total 8 articles about Acetamide, 2-chloro-N-(2,3-dihydroxypropyl)-N-(phenylmethyl)-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 148638-77-1
N-Benzyl-2-chloro-N-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-acetamide

: 135065-72-4
(S)-N-benzyl-3-chloroacetamidopropane-1,2-diol

Guidance literature:: With acetic acid; at 90 ℃; for 1h;

Reference yield:

: 79-04-9
chloroacetyl chloride

: 100-46-9
benzylamine

: 1707-77-3
1,2:5,6-di-O-isopropylidene-D-mannitol

: 135065-72-4
(S)-N-benzyl-3-chloroacetamidopropane-1,2-diol

Guidance literature:: With sodium periodate; sodium hydrogencarbonate; triethylamine; aluminum nickel; In ethanol; water; acetic acid; ethyl acetate;

Reference yield:

: 109208-40-4
N-benzyl-N-amine

: 135065-72-4
(S)-N-benzyl-3-chloroacetamidopropane-1,2-diol

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

2: 100 percent / 20percent aq. CH₃COOH / 0.83 h / 70 °C

3: 97 percent / pyridine / CH₂Cl₂ / a) 0 deg C, 1 h, b) 20-25 deg C, 16 h

4: 90 percent / butan-2-one / 40 h / Heating

5: 6N HCl / 40 h / Heating

6: Et₃N / 1 h / 20 - 25 °C

With pyridine; hydrogenchloride; acetic acid; triethylamine; In dichloromethane; butanone;