(3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine

Base Information

Chemical Name:(3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine
CAS No.:754206-43-4
Molecular Formula:C₂₀H₂₄FNO₃S
Molecular Weight:377.48
Hs Code.:

Synonyms:(3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine

Suppliers and Price of (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine

There total 1 articles about (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 124-63-0
methanesulfonyl chloride

: 201855-64-3,188869-25-2
(3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine

: 754206-43-4
(3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/ejoc.200400067

Reference yield: 78.5%

: 533-31-3
Sesamol

: 754206-43-4
(3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine

: (3S,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[3,4-(methylenedioxy)-phenoxy]methyl}piperidine hydrochloride

Guidance literature:: Sesamol; (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine; With sodium hydroxide; In iso-butanol; xylene; for 10h; Heating;

With hydrogenchloride; In isopropyl alcohol; pH=2;
DOI:10.1002/ejoc.200400067

Reference yield:

: 754206-43-4
(3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine

: 110429-35-1,130855-30-0
(-)-paroxetine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / xylene; butan-2-ol / 10 h / Heating

1.2: 78.5 percent / aq. HCl / propan-2-ol / pH 2

2.1: 89.5 percent / H₂ / Pd/C / propan-2-ol / 3 h / 40 °C / 375.03 - 3750.3 Torr

With sodium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; iso-butanol; xylene;
DOI:10.1002/ejoc.200400067