methyl 4'-(2-hydroxyethyl)-3-(quinoline-2-carbonylamino)-[1,1'-biphenyl]-4-carboxylate

Base Information

Chemical Name:methyl 4'-(2-hydroxyethyl)-3-(quinoline-2-carbonylamino)-[1,1'-biphenyl]-4-carboxylate
CAS No.:1426536-79-9
Molecular Formula:C₂₆H₂₂N₂O₄
Molecular Weight:426.472
Hs Code.:

Synonyms:methyl 4'-(2-hydroxyethyl)-3-(quinoline-2-carbonylamino)-[1,1'-biphenyl]-4-carboxylate

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Chemical Property of methyl 4'-(2-hydroxyethyl)-3-(quinoline-2-carbonylamino)-[1,1'-biphenyl]-4-carboxylate

Chemical Property:

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Technology Process of methyl 4'-(2-hydroxyethyl)-3-(quinoline-2-carbonylamino)-[1,1'-biphenyl]-4-carboxylate

There total 3 articles about methyl 4'-(2-hydroxyethyl)-3-(quinoline-2-carbonylamino)-[1,1'-biphenyl]-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135484-83-2
2-amino-4-bromo-benzoic acid methyl ester

: 1426536-79-9
methyl 4'-(2-hydroxyethyl)-3-(quinoline-2-carbonylamino)-[1,1'-biphenyl]-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / tetrahydrofuran / 15 h / 80 °C

2: triethylamine / dichloromethane / 40 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; 1: |Suzuki Coupling;
DOI:10.1021/ml4000832

Reference yield:

: C₂₂H₃₁NO₃Si

: 1426536-79-9
methyl 4'-(2-hydroxyethyl)-3-(quinoline-2-carbonylamino)-[1,1'-biphenyl]-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 40 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml4000832

Reference yield:

: 1035099-75-2
(4-{2-[(tert-butyldimethylsilyl)oxy]ethyl}phenyl)boronic acid

: 1426536-79-9
methyl 4'-(2-hydroxyethyl)-3-(quinoline-2-carbonylamino)-[1,1'-biphenyl]-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / tetrahydrofuran / 15 h / 80 °C

2: triethylamine / dichloromethane / 40 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; 1: |Suzuki Coupling;
DOI:10.1021/ml4000832