Technology Process of 4-phenyl-1,5-hexadien-3-ol
There total 9 articles about 4-phenyl-1,5-hexadien-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
for 1.5h;
DOI:10.1021/jo00289a053
- Guidance literature:
-
trimethyl-[1-(1-phenyl-allyloxy)-allyl]-silane;
With
cesium fluoride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
With
hydrogenchloride; ammonium chloride;
In
diethyl ether; N,N-dimethyl-formamide;
Further stages.;
DOI:10.1021/ol9909132
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) isopropylmagnesium bromide / 1) THF, 4 h, room temp., 2) 30 min, 0 deg C
2: diethyl ether
3: 84 percent / imidazole / dimethylformamide
4: 85 percent / diisobutylaluminum hydride / benzene; hexane / 1 h
5: 60 percent / pyridinum dichromate / CH2Cl2 / 60 h
6: 73 percent / tetrahydrofuran / 0.5 h / -78 °C
7: 75 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h
With
1H-imidazole; dipyridinium dichromate; tetrabutyl ammonium fluoride; isopropylmagnesium bromide; diisobutylaluminium hydride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00289a053
