5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid

Base Information

Chemical Name:5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid
CAS No.:1312697-77-0
Molecular Formula:C₂₁H₁₅Cl₂F₃N₂O₃
Molecular Weight:471.263
Hs Code.:

Synonyms:5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid

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Chemical Property of 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid

Chemical Property:

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Technology Process of 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid

There total 10 articles about 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312697-81-6
5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid methyl ester

: 1312697-77-0
5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid

Guidance literature:: 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid methyl ester; With lithium hydroxide; In tetrahydrofuran; methanol;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=3;

Reference yield:

: 53277-47-7
2-chloro-6-methylnicotinic acid methyl ester

: 1312697-77-0
5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 19 h / 110 °C

2.1: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

3.1: hydroxylamine / water; tetrahydrofuran

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.33 h / 40 °C

4.2: 20 °C

5.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 40 h / 50 °C

6.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

7.1: copper(II) cyanide / formaldehyde diethyl acetal; tetrahydrofuran / -75 °C

7.2: 5 h / 130 °C / Inert atmosphere

8.1: lithium hydroxide / tetrahydrofuran; methanol

8.2: pH 3

With sodium periodate; N-chloro-succinimide; hydroxylamine; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(II) cyanide; In tetrahydrofuran; methanol; formaldehyde diethyl acetal; water; N,N-dimethyl-formamide;

Reference yield:

: 30529-70-5
2-chloro-6-methyl nicotinic acid

: 1312697-77-0
5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-1,3-dimethylindolizine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: oxalyl dichloride / dichloromethane / 0.5 h

2.1: dichloromethane / 0 °C

3.1: N,N-dimethyl-formamide / 19 h / 110 °C

4.1: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

5.1: hydroxylamine / water; tetrahydrofuran

6.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.33 h / 40 °C

6.2: 20 °C

7.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 40 h / 50 °C

8.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

9.1: copper(II) cyanide / formaldehyde diethyl acetal; tetrahydrofuran / -75 °C

9.2: 5 h / 130 °C / Inert atmosphere

10.1: lithium hydroxide / tetrahydrofuran; methanol

10.2: pH 3

With sodium periodate; N-chloro-succinimide; oxalyl dichloride; hydroxylamine; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(II) cyanide; In tetrahydrofuran; methanol; formaldehyde diethyl acetal; dichloromethane; water; N,N-dimethyl-formamide;