(R)-N-{(2S,3R)-3-[bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-{(2S,3R)-3-[bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}-2-methylpropane-2-sulfinamide
CAS No.:1612891-54-9
Molecular Formula:C₂₉H₃₅F₃N₂O₃S
Molecular Weight:548.67
Hs Code.:

Synonyms:(R)-N-{(2S,3R)-3-[bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-{(2S,3R)-3-[bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-{(2S,3R)-3-[bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}-2-methylpropane-2-sulfinamide

There total 5 articles about (R)-N-{(2S,3R)-3-[bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1612891-53-8
(R,E)-N-{(R)-2-[bis(4-methoxybenzyl)amino]-2-phenylethylidene}-2-methylpropane-2-sulfinamide

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1612891-54-9
(R)-N-{(2S,3R)-3-[bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}-2-methylpropane-2-sulfinamide

Guidance literature:: With tetramethylammonium fluoride; In tetrahydrofuran; at -35 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo500832j

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 1612891-54-9
(R)-N-{(2S,3R)-3-[bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 60 h / 60 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.83 h / -78 °C / Inert atmosphere

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 0 °C / Inert atmosphere

4.1: tetramethylammonium fluoride / tetrahydrofuran / 1 h / -35 °C / Inert atmosphere

With titanium(IV) tetraethanolate; oxalyl dichloride; tetramethylammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane; acetonitrile; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo500832j

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1612891-54-9
(R)-N-{(2S,3R)-3-[bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 60 h / 60 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.83 h / -78 °C / Inert atmosphere

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 0 °C / Inert atmosphere

4.1: tetramethylammonium fluoride / tetrahydrofuran / 1 h / -35 °C / Inert atmosphere

With titanium(IV) tetraethanolate; oxalyl dichloride; tetramethylammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane; acetonitrile; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo500832j