(R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol

Base Information

Chemical Name:(R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol
CAS No.:1279712-55-8
Molecular Formula:C₂₃H₄₁IO₄Si
Molecular Weight:536.566
Hs Code.:

Synonyms:(R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol

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Technology Process of (R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol

There total 7 articles about (R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1279712-54-7
(R,S)-1-(3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol

: 1279712-55-8
(R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol

Guidance literature:: (R,S)-1-(3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol; With n-butyllithium; In hexane; toluene; at -50 - 20 ℃; for 4.25h;

With iodine; In tetrahydrofuran; hexane; toluene; at -50 - 20 ℃;
DOI:10.1002/chem.201003166

Reference yield:

: 629-11-8
1,6-hexanediol

: 1279712-55-8
(R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

1.2: 2.5 h / 0 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.17 h / -78 °C

2.2: 1.75 h / -78 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

3.2: 1.25 h / -78 °C

3.3: -78 - 20 °C

4.1: n-butyllithium / hexane; toluene / 4.25 h / -50 - 20 °C

4.2: -50 - 20 °C

With n-butyllithium; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; hexane; dichloromethane; toluene; mineral oil; 2.1: Swern oxidation / 2.2: Swern oxidation;
DOI:10.1002/chem.201003166

Reference yield:

: 245124-09-8
6-((triisopropylsilyl)oxy)hexanal

: 1279712-55-8
(R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 1.25 h / -78 °C

1.3: -78 - 20 °C

2.1: n-butyllithium / hexane; toluene / 4.25 h / -50 - 20 °C

2.2: -50 - 20 °C

With n-butyllithium; In tetrahydrofuran; hexane; toluene;
DOI:10.1002/chem.201003166