(R,S)-2-tert-butyl 1-(1'-(2''-iodo-3''-(methoxymethoxy)phenyl)-6'-(triisopropylsilyloxy)hexyl) 3,8-dimethoxy-9,10-anthraquinone-1,2-dicarboxylate

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Chemical Name:(R,S)-2-tert-butyl 1-(1'-(2''-iodo-3''-(methoxymethoxy)phenyl)-6'-(triisopropylsilyloxy)hexyl) 3,8-dimethoxy-9,10-anthraquinone-1,2-dicarboxylate
CAS No.:1279712-56-9
Molecular Formula:C₄₅H₅₉IO₁₁Si
Molecular Weight:930.947
Hs Code.:

Synonyms:(R,S)-2-tert-butyl 1-(1'-(2''-iodo-3''-(methoxymethoxy)phenyl)-6'-(triisopropylsilyloxy)hexyl) 3,8-dimethoxy-9,10-anthraquinone-1,2-dicarboxylate

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Chemical Property of (R,S)-2-tert-butyl 1-(1'-(2''-iodo-3''-(methoxymethoxy)phenyl)-6'-(triisopropylsilyloxy)hexyl) 3,8-dimethoxy-9,10-anthraquinone-1,2-dicarboxylate

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Technology Process of (R,S)-2-tert-butyl 1-(1'-(2''-iodo-3''-(methoxymethoxy)phenyl)-6'-(triisopropylsilyloxy)hexyl) 3,8-dimethoxy-9,10-anthraquinone-1,2-dicarboxylate

There total 11 articles about (R,S)-2-tert-butyl 1-(1'-(2''-iodo-3''-(methoxymethoxy)phenyl)-6'-(triisopropylsilyloxy)hexyl) 3,8-dimethoxy-9,10-anthraquinone-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1279712-55-8
(R,S)-1-(2'-iodo-3'-(methoxymethoxy)phenyl)-6-(triisopropylsilyloxy)hexan-1-ol

: 1279712-51-4
2-(tert-butoxycarbonyl)-3,8-dimethoxy-9,10-anthraquinone-1-carboxylic acid

: 1279712-56-9
(R,S)-2-tert-butyl 1-(1'-(2''-iodo-3''-(methoxymethoxy)phenyl)-6'-(triisopropylsilyloxy)hexyl) 3,8-dimethoxy-9,10-anthraquinone-1,2-dicarboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;
DOI:10.1002/chem.201003166

Reference yield:

: 954416-12-7
tert-butyl 3,8-dimethoxy-1-methyl-9,10-anthraquinone-2-carboxylate

: 1279712-56-9
(R,S)-2-tert-butyl 1-(1'-(2''-iodo-3''-(methoxymethoxy)phenyl)-6'-(triisopropylsilyloxy)hexyl) 3,8-dimethoxy-9,10-anthraquinone-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux

2: 4-methylmorpholine N-oxide / dimethyl sulfoxide / 20 h / 20 °C

3: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water / 17 h / 0 - 21 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.5 h / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; 4-methylmorpholine N-oxide; triphenylphosphine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water; dimethyl sulfoxide; 3: Pinnick oxidation;
DOI:10.1002/chem.201003166

Reference yield:

: 591-20-8
3-Bromophenol

: 1279712-56-9
(R,S)-2-tert-butyl 1-(1'-(2''-iodo-3''-(methoxymethoxy)phenyl)-6'-(triisopropylsilyloxy)hexyl) 3,8-dimethoxy-9,10-anthraquinone-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2.67 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: 1.25 h / -78 °C

2.3: -78 - 20 °C

3.1: n-butyllithium / hexane; toluene / 4.25 h / -50 - 20 °C

3.2: -50 - 20 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.5 h / 0 - 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.201003166