Technology Process of (R)-3-Benzyloxy-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol
There total 5 articles about (R)-3-Benzyloxy-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: L-(-)-diethyl tartrate; Ti(iPrO)4; TBHP / 4 Angstroem molecular sieves
2: Ti(iPrO)4 / toluene / 72 h / Heating
3: p-toluenesulfonic acid / CH2Cl2 / 0.5 h
4: 1.2 g / TBAF / tetrahydrofuran
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(-)-diethyl tartrate; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid;
4 A molecular sieve;
In
tetrahydrofuran; dichloromethane; toluene;
1: Sharpless asymmetric epoxidation;
DOI:10.1021/jm034216y
- Guidance literature:
-
Multi-step reaction with 5 steps
1: DIBAL-H / CH2Cl2; cyclohexane / 0.5 h / -78 - 20 °C
2: L-(-)-diethyl tartrate; Ti(iPrO)4; TBHP / 4 Angstroem molecular sieves
3: Ti(iPrO)4 / toluene / 72 h / Heating
4: p-toluenesulfonic acid / CH2Cl2 / 0.5 h
5: 1.2 g / TBAF / tetrahydrofuran
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(-)-diethyl tartrate; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; toluene-4-sulfonic acid;
4 A molecular sieve;
In
tetrahydrofuran; dichloromethane; cyclohexane; toluene;
2: Sharpless asymmetric epoxidation;
DOI:10.1021/jm034216y
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
DOI:10.1021/jm034216y