(2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol

Base Information

• Chemical Name: (2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol
• CAS No.: 116003-84-0
• Molecular Formula: C₂₁H₂₈O₃Si
• Molecular Weight: 356.537
• Mol file: 116003-84-0.mol

Synonyms:(2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol

Chemical Property of (2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol

There total 16 articles about (2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(E)-5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-en-1-ol (127665-77-4) → (2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol (116003-84-0)

Guidance literature:

(E)-5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-en-1-ol; With titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; 4 A molecular sieve; In dichloromethane; at -20 ℃; for 0.5h;

With tert.-butylhydroperoxide; In dichloromethane; toluene; at -20 ℃; for 3h;

DOI:10.1016/j.tet.2003.09.070

Reference yield: 81.0%

(E)-5-(tert-Butyl-diphenyl-silanyloxy)-pent-2-en-1-ol (656238-49-2) → (2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol (116003-84-0)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; In dichloromethane; at -20 ℃;

DOI:10.1016/j.carres.2021.108484

Reference yield: 75.0%

C29H41NO4SSi (1195778-61-0) → (2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol (116003-84-0)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/b912070j

upstream raw materials:

(E)-5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-en-1-ol

3-(tert-butyldiphenylsilyloxy)-1-propanal

3-(tert-butyldiphenylsilyloxy)propan-1-ol

tert-butylchlorodiphenylsilane

Downstream raw materials:

(2R,3S)-3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)oxirane-2-carbaldehyde

(2S,3R)-1,2-dihydro-5-tertbutyldiphenylsilyloxy-pentan-3-yl 2-(phenylthio)acetate

(3S,4R,5R)-4,5-diallyl-3-phenylthio-dihydrofuran-2-one

(3S,4R,5R)-4-allyl-5-(2-hydroxyethyl)-3-phenylthio-dihydrofuran-2-one