Malonic acid dodecyl ester (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester

Base Information

• Chemical Name: Malonic acid dodecyl ester (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester
• CAS No.: 212513-23-0
• Molecular Formula: C₃₈H₄₈O₇
• Molecular Weight: 616.795

Synonyms:Malonic acid dodecyl ester (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester

Chemical Property of Malonic acid dodecyl ester (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester

Chemical Property:

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Technology Process of Malonic acid dodecyl ester (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester

There total 2 articles about Malonic acid dodecyl ester (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-dodecyl alcohol (112-53-8) + methyl (R)-2-[((tert-butylthio)carbonyl)acetyloxy]-3-triphenylmethyloxypropionate (212513-10-5) → Malonic acid dodecyl ester (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (212513-23-0)

Guidance literature:

With silver trifluoroacetate; In tetrahydrofuran; at 23 ℃;

DOI:10.1021/jm0100741

Reference yield:

methyl (2R)-2-methoxy-3-(triphenylmethoxy)propanoate (16814-88-3) → Malonic acid dodecyl ester (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (212513-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / DCC / CH₂Cl₂ / 2 h / 0 °C

2: silver trifluoroacetate / tetrahydrofuran / 23 °C

With silver trifluoroacetate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0100741

Reference yield:

Malonic acid dodecyl ester (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (212513-23-0) → (R)-4-Hydroxy-2-oxo-5-trityloxymethyl-2,5-dihydro-furan-3-carboxylic acid dodecyl ester

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃;

DOI:10.1021/jm0100741

upstream raw materials:

1-dodecyl alcohol

methyl (R)-2-[((tert-butylthio)carbonyl)acetyloxy]-3-triphenylmethyloxypropionate

methyl (2R)-2-methoxy-3-(triphenylmethoxy)propanoate

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