6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide

Base Information

Chemical Name:6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide
CAS No.:1445791-66-1
Molecular Formula:C₂₅H₃₀ClN₃O₄S
Molecular Weight:504.05
Hs Code.:

Synonyms:6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide

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Chemical Property of 6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of 6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide

There total 13 articles about 6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1445790-48-6
(3-amino-5-cyclopentylphenyl)methanol

: 1445791-64-9
6-butoxy-4,7-dichloroquinoline-3-sulfonamide

: 1445791-66-1
6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide

Guidance literature:: In ethanol; for 1h; Reflux;

Reference yield:

: 7-chloro-4-hydroxy-6-methoxyquinoline-3-carboxylic acid

: 1445791-66-1
6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / Reflux

2.1: hydrogenchloride; sodium nitrite / water / -5 - 0 °C

2.2: -5 °C

3.1: ammonium hydroxide / tetrahydrofuran

4.1: boron tribromide / 1,2-dichloro-ethane / 12 h / 60 °C

5.1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 50 °C

6.1: ethanol / 1 h / Reflux

With hydrogenchloride; ammonium hydroxide; thionyl chloride; boron tribromide; potassium carbonate; N,N-dimethyl-formamide; sodium iodide; sodium nitrite; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1445790-46-4
methyl 3-amino-5-cyclopentylbenzoate

: 1445791-66-1
6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

2: ethanol / 1 h / Reflux

With lithium aluminium tetrahydride; In tetrahydrofuran; ethanol;