6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Base Information

Chemical Name:6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide
CAS No.:1445788-22-6
Molecular Formula:C₃₁H₃₇N₅O₆S
Molecular Weight:607.731
Hs Code.:

Synonyms:6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

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Chemical Property of 6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

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Technology Process of 6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

There total 14 articles about 6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1445791-66-1
6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-sulfonamide

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445788-22-6
6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 2.5h;

Reference yield:

: 7-chloro-4-hydroxy-6-methoxyquinoline-3-carboxylic acid

: 1445788-22-6
6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / Reflux

2.1: hydrogenchloride; sodium nitrite / water / -5 - 0 °C

2.2: -5 °C

3.1: ammonium hydroxide / tetrahydrofuran

4.1: boron tribromide / 1,2-dichloro-ethane / 12 h / 60 °C

5.1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 50 °C

6.1: ethanol / 1 h / Reflux

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C

With hydrogenchloride; ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; boron tribromide; potassium carbonate; N,N-dimethyl-formamide; sodium iodide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1445790-46-4
methyl 3-amino-5-cyclopentylbenzoate

: 1445788-22-6
6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

2: ethanol / 1 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water;