5-Pyrimidinecarboxamide, 2-amino-N-(1-benzyl-4-piperidyl)-4-methoxy-

Base Information

Chemical Name:5-Pyrimidinecarboxamide, 2-amino-N-(1-benzyl-4-piperidyl)-4-methoxy-
CAS No.:72412-43-2
Molecular Formula:C₁₈H₂₃N₅O₂
Molecular Weight:341.413
Hs Code.:
DSSTox Substance ID:DTXSID50222710
Nikkaji Number:J70.315J
Wikidata:Q83101026
Mol file:72412-43-2.mol

Synonyms:72412-43-2;BRN 5609746;5-Pyrimidinecarboxamide, 2-amino-N-(1-benzyl-4-piperidyl)-4-methoxy-;2-Amino-N-(1-benzyl-4-piperidyl)-4-methoxy-5-pyrimidinecarboxamide;2-Amino-N-(1-benzyl-4-piperidinyl)-4-methoxy-5-pyrimidinecarboxamide;2-amino-N-(1-benzylpiperidin-4-yl)-4-methoxypyrimidine-5-carboxamide;DTXSID50222710;LS-134717

Suppliers and Price of 5-Pyrimidinecarboxamide, 2-amino-N-(1-benzyl-4-piperidyl)-4-methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-AMINO-N-(1-BENZYL-4-PIPERIDYL)-4-METHOXY-5-PYRIMIDINE CARBOXAMIDE 95.00%
5MG
$ 501.66

Total 3 raw suppliers

Chemical Property of 5-Pyrimidinecarboxamide, 2-amino-N-(1-benzyl-4-piperidyl)-4-methoxy-

Chemical Property:

PSA：97.59000
Density:1.27g/cm³
LogP:1.90460
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:341.18517499
Heavy Atom Count:25
Complexity:422

Purity/Quality:

99% ^*data from raw suppliers

2-AMINO-N-(1-BENZYL-4-PIPERIDYL)-4-METHOXY-5-PYRIMIDINE CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=NC(=NC=C1C(=O)NC2CCN(CC2)CC3=CC=CC=C3)N

Technology Process of 5-Pyrimidinecarboxamide, 2-amino-N-(1-benzyl-4-piperidyl)-4-methoxy-

There total 5 articles about 5-Pyrimidinecarboxamide, 2-amino-N-(1-benzyl-4-piperidyl)-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15400-53-0
ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate

: 72412-43-2
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-piperidin-4-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / pyridine / 2 h / Heating

2: 81 percent / phosphorus oxychloride / 2 h / 60 °C

3: 95 percent / sodium / Ambient temperature

4: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In pyridine; methanol; water;

Reference yield:

: 72419-36-4
2-amino-4-methoxy-5-methoxycarbonilpyrimidine

: 72412-43-2
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-piperidin-4-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 344311-74-6
2-Acetylamino-4-hydroxy-pyrimidine-5-carboxylic acid ethyl ester

: 72412-43-2
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-piperidin-4-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / phosphorus oxychloride / 2 h / 60 °C

2: 95 percent / sodium / Ambient temperature

3: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

4: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In methanol; water;