(R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine

Base Information

Chemical Name:(R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine
CAS No.:501692-76-8
Molecular Formula:C₂₄H₃₀N₂O₆
Molecular Weight:442.512
Hs Code.:

Synonyms:(R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine

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Chemical Property of (R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine

Chemical Property:

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Technology Process of (R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine

There total 2 articles about (R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26787-75-7
(R)-2-(((benzyloxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid

: 75190-94-2
(2S)-2-amino-butanoic acid t-butyl ester

: 501692-76-8
(R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 18 - 25 ℃; Inert atmosphere;

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 501-53-1,94274-21-2
benzyl chloroformate

: 501692-76-8
(R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water / 2.33 h / 18 - 25 °C / Inert atmosphere

2: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 18 - 25 °C / Inert atmosphere

With 4-methyl-morpholine; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; water;

Reference yield: 81.0%

: 501692-76-8
(R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine

: tert-butyl (2S)-2-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}butanoate hydrochloride

Guidance literature:: (R)-N-benzyloxycarbonyl-α-{N-[(S)-1-(t-butoxycarbonyl)propyl]carbamoyl}-4-hydroxybenzylamine; With hydrogen; 5%-palladium/activated carbon; In ethanol; at 20 ℃; for 20h; under 750.075 Torr;

With pyridine hydrochloride; In acetonitrile; for 60h;