2-(3-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide

Base Information

Chemical Name:2-(3-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide
CAS No.:1616074-97-5
Molecular Formula:C₂₂H₂₇N₃O₄
Molecular Weight:397.474
Hs Code.:

Synonyms:2-(3-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide

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Chemical Property of 2-(3-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide

Chemical Property:

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Technology Process of 2-(3-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide

There total 4 articles about 2-(3-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 6339-04-4
2-(3-acetamidophenoxy)acetic acid

: 954279-15-3
1-amino-3-(3,4-dihydroisoquinoline-2(1H)-yl)propan-2-ol

: 1616074-97-5
2-(3-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 25 ℃; for 3h;

Reference yield:

: 140406-65-1
2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline

: 1616074-97-5
2-(3-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / ethanol / 3 h / -78 - 80 °C / Sealed tube

2: triethylamine; HATU / dichloromethane / 3 h / 25 °C

With ammonia; triethylamine; HATU; In ethanol; dichloromethane;

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1616074-97-5
2-(3-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 1 h / 0 °C

1.2: 16 h / 22 °C

2.1: ammonia / ethanol / 3 h / -78 - 80 °C / Sealed tube

3.1: triethylamine; HATU / dichloromethane / 3 h / 25 °C

With ammonia; potassium carbonate; triethylamine; HATU; In ethanol; dichloromethane; acetonitrile;