C₄₄H₇₅IOSi

Base Information

• Chemical Name: C₄₄H₇₅IOSi
• CAS No.: 1454597-87-5
• Molecular Formula: C₄₄H₇₅IOSi
• Molecular Weight: 775.069
• Mol file: 1454597-87-5.mol

Synonyms:C₄₄H₇₅IOSi

Chemical Property of C₄₄H₇₅IOSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₇₅IOSi

There total 27 articles about C₄₄H₇₅IOSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C44H76O2Si (1454597-85-3) → C44H75IOSi (1454597-87-5)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In diethyl ether; acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1002/anie.201303776

Reference yield:

C35H61NO5 (1454597-79-5) + tert-butyldiphenylsilyl triflate (92886-86-7) → C44H75IOSi (1454597-87-5)

Guidance literature:

C₃₅H₆₁NO₅; With 1H-imidazole; dmap; tert-butyldimethylsilyl chloride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

With potassium carbonate; In methanol; for 6h; Reflux; Inert atmosphere;

tert-butyldiphenylsilyl triflate; Further stages;

DOI:10.1002/chem.201404034

Reference yield:

(S)-Octadec-1-yn-3-ol → C44H75IOSi (1454597-87-5)

Guidance literature:

Multi-step reaction with 12 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.1: water; sodium hydroxide / methanol / 1 h / Reflux

3.1: methyllithium / tetrahydrofuran / 0.67 h / -20 - 20 °C / Inert atmosphere

3.2: 1 h / 40 °C / Inert atmosphere

3.3: 0.25 h / 0 °C / Inert atmosphere

4.1: tert.-butyl lithium / diethyl ether; pentane / 0.17 h / -78 °C / Inert atmosphere

4.2: 2 h / -78 - 20 °C / Inert atmosphere

4.3: 2 h / 20 °C / Darkness

5.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: tetra-N-butylammonium tribromide / methanol / 4 h / 20 °C / Inert atmosphere

7.1: hydrogen; [Ir(cod)(SIMes)(Pyr)]⁺PF₆^- / dichloromethane / 18 h / 20 °C / 67506.8 Torr / Autoclave

8.1: 1H-imidazole; dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

9.1: potassium carbonate / methanol / 6 h / 60 °C / Inert atmosphere

10.1: 2,6-dimethylpyridine / dichloromethane / 5 h / 0 °C / Inert atmosphere

11.1: tetra-N-butylammonium tribromide / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

12.1: triphenylphosphine; iodine; 1H-imidazole / acetonitrile; diethyl ether / 0.25 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; dmap; di-isopropyl azodicarboxylate; [Ir(cod)(SIMes)(Pyr)]⁺PF₆^-; water; methyllithium; hydrogen; iodine; tert.-butyl lithium; tetra-N-butylammonium tribromide; potassium carbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile; pentane;

DOI:10.1002/anie.201303776

upstream raw materials:

C₁₈H₃₅IO

octadec-1-yn-3-ol

C₁₆H₃₆O₂Si

C₁₆H₃₅IOSi