3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid

Base Information

Chemical Name:3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid
CAS No.:330580-68-2
Molecular Formula:C₁₇H₁₄N₂O₅
Molecular Weight:326.309
Hs Code.:

Synonyms:3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid

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Chemical Property of 3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid

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Technology Process of 3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid

There total 8 articles about 3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 330580-67-1
3,4-dihydro-3-[4-methoxybenzyl(phenylacetyl)amino]-2-oxobenz[e][1,3]oxazine-7-carboxylic acid

: 330580-68-2
3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid

Guidance literature:: With methanesulfonic acid; trifluoroacetic acid; at 20 ℃; for 48h;
DOI:10.1002/1099-0690(200101)2001:1<141::aid-ejoc141>3.0.co;2-j

Reference yield:

: 619-12-5
4-formyl-3-hydroxybenzoic acid

: 330580-68-2
3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / Et₃N / methanol / 16 h / Heating

2: 68 percent / NaBH₃CN; CF₃CO₂H / methanol / 16 h / 20 °C / pH 3

3: 60 percent / Et₃N / tetrahydrofuran / 4 h / Heating

4: 71 percent / MeSO₃H; CF₃CO₂H / 48 h / 20 °C

With methanesulfonic acid; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1002/1099-0690(200101)2001:1<141::aid-ejoc141>3.0.co;2-j

Reference yield:

: 103-80-0
phenylacetyl chloride

: 330580-68-2
3,4-dihydro-3-[(phenylacetyl)amino]-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / 1 N NaOH / 3 h / 20 °C

2: AcOH; Ac₂O; NaNO₂ / 0 - 20 °C

3: 0.48 g / Zn dust; AcOH / ethyl acetate / 3 h / 20 °C

4: 67 percent / Et₃N / methanol / 16 h / Heating

5: 68 percent / NaBH₃CN; CF₃CO₂H / methanol / 16 h / 20 °C / pH 3

6: 60 percent / Et₃N / tetrahydrofuran / 4 h / Heating

7: 71 percent / MeSO₃H; CF₃CO₂H / 48 h / 20 °C

With sodium hydroxide; methanesulfonic acid; acetic anhydride; sodium cyanoborohydride; acetic acid; triethylamine; trifluoroacetic acid; zinc; sodium nitrite; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1002/1099-0690(200101)2001:1<141::aid-ejoc141>3.0.co;2-j