N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

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Chemical Name:N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide
CAS No.:1448855-88-6
Molecular Formula:C₃₈H₄₉N₉O₆S
Molecular Weight:759.93
Hs Code.:

N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

Synonyms:N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

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Chemical Property of N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

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Technology Process of N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

There total 9 articles about N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1247948-34-0
5-oxo-5-(phenylthio)pentanoic acid

: 159539-41-0
microgonotropen

: 1448855-88-6
N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2013.05.126

Reference yield:

: 913960-96-0
C₂₂H₂₈N₈O₅

: 1448855-88-6
N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 0.75 h

2: triethylamine / N,N-dimethyl-formamide / 8.5 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide; acetone / 8 h / Inert atmosphere; Reflux

4: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2013.05.126

Reference yield:

: 913960-95-9
1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

: 1448855-88-6
N-[3-(dimethylamine)propyl]-1-methyl-4-[(1-{3-(5-oxo-5-[phenylthio]pentanamido)propyl}-4-{[1-methyl-4-(methylcarboxamido)-1H-2-pyrrolyl]carboxamido}-1H-2-pyrrolyl)carboxamido]-1H-2-pyrrolecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide; methanol / 1 h / 20 °C

2: dmap; diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

3: hydrogen; palladium 10% on activated carbon / methanol / 0.75 h

4: triethylamine / N,N-dimethyl-formamide / 8.5 h / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide; acetone / 8 h / Inert atmosphere; Reflux

6: trifluoroacetic acid / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere

7: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With dmap; diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2013.05.126