1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

Base Information

Chemical Name:1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide
CAS No.:913960-95-9
Molecular Formula:C₁₆H₂₂N₆O₄
Molecular Weight:362.388
Hs Code.:

Synonyms:1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

Suppliers and Price of 1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

There total 1 articles about 1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 5930-93-8
4-nitropyrrole-2-carboxylic acid

: 78486-14-3
3-(1-methyl-4-aminopyrrole-2-carbonylamino)propyldimethylamine

: 913960-95-9
1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

Guidance literature:: With dmap; diethyl chlorophosphate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/ol061551i

Reference yield:

: 913960-95-9
1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

: 913960-98-2
{4-[(4-acetylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-2-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-pyrrol-1-yl}-thioacetic acid S-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / methanol; dimethylformamide / 1 h / 20 °C

2: 489 mg / DECP; Et₃N; DMAP / tetrahydrofuran; dimethylformamide / 8.33 h / 0 - 20 °C

3: H₂ / Pd/C / methanol / 1.5 h / 20 °C

4: 310 mg / Et₃N / dimethylformamide / 5.5 h / 0 - 20 °C

5: 45 percent / K₂CO₃ / acetone; dimethylformamide / 8 h / Heating

With dmap; hydrogen; potassium carbonate; diethyl chlorophosphate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol061551i

Reference yield:

: 913960-95-9
1-Methyl-4-[(4-nitro-1H-pyrrole-2-carbonyl)-amino]-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

: 922139-32-0
[1-(3-{4-[(4-acetylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-2-[5-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-pyrrol-1-yl}-propylcarbamoyl)-2-tritylsulfanyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd/C / methanol; dimethylformamide / 1 h / 20 °C

2: 489 mg / DECP; Et₃N; DMAP / tetrahydrofuran; dimethylformamide / 8.33 h / 0 - 20 °C

3: H₂ / Pd/C / methanol / 1.5 h / 20 °C

4: 310 mg / Et₃N / dimethylformamide / 5.5 h / 0 - 20 °C

5: 50 percent / K₂CO₃ / acetone; dimethylformamide / 8 h / Heating

6: TFA / CH₂Cl₂ / 3 h / 0 - 20 °C

7: 27 mg / HBTU; HOBt; DIEA / dimethylformamide / 3 h / 20 °C

With dmap; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethyl chlorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol061551i