(2-{1-[2-(1,3-Diphenyl-ureido)-ethyl]-3-phenyl-ureido}-ethyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (2-{1-[2-(1,3-Diphenyl-ureido)-ethyl]-3-phenyl-ureido}-ethyl)-carbamic acid tert-butyl ester
• CAS No.: 174497-03-1
• Molecular Formula: C₂₉H₃₅N₅O₄
• Molecular Weight: 517.628

Synonyms:(2-{1-[2-(1,3-Diphenyl-ureido)-ethyl]-3-phenyl-ureido}-ethyl)-carbamic acid tert-butyl ester

Chemical Property of (2-{1-[2-(1,3-Diphenyl-ureido)-ethyl]-3-phenyl-ureido}-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of (2-{1-[2-(1,3-Diphenyl-ureido)-ethyl]-3-phenyl-ureido}-ethyl)-carbamic acid tert-butyl ester

There total 3 articles about (2-{1-[2-(1,3-Diphenyl-ureido)-ethyl]-3-phenyl-ureido}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

phenyl isocyanate (103-71-9) + [2-(2-Phenylamino-ethylamino)-ethyl]-carbamic acid tert-butyl ester (174497-02-0) → (2-{1-[2-(1,3-Diphenyl-ureido)-ethyl]-3-phenyl-ureido}-ethyl)-carbamic acid tert-butyl ester (174497-03-1)

Guidance literature:

In 1,2-dichloro-ethane; for 21h; Heating;

DOI:10.1021/ja9536072

Reference yield:

N-(t-butoxycarbonyl)glycinal (89711-08-0) → (2-{1-[2-(1,3-Diphenyl-ureido)-ethyl]-3-phenyl-ureido}-ethyl)-carbamic acid tert-butyl ester (174497-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / H₂ / 10percent Pd/C / methanol / 16 h

2: 79 percent / 1,2-dichloro-ethane / 21 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane;

DOI:10.1021/ja9536072

Reference yield:

N-(2-aminoethyl)benzeneamine (1664-40-0) → (2-{1-[2-(1,3-Diphenyl-ureido)-ethyl]-3-phenyl-ureido}-ethyl)-carbamic acid tert-butyl ester (174497-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / H₂ / 10percent Pd/C / methanol / 16 h

2: 79 percent / 1,2-dichloro-ethane / 21 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane;

DOI:10.1021/ja9536072

upstream raw materials:

phenyl isocyanate

[2-(2-Phenylamino-ethylamino)-ethyl]-carbamic acid tert-butyl ester

N-(t-butoxycarbonyl)glycinal

N-(2-aminoethyl)benzeneamine

Downstream raw materials:

(S)-2-(3-(2-tert-Butoxycarbonylamino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

C₂₄H₂₇N₅O₂

C₂₇H₃₀N₆O₂

(S)-2-(3-(2-Amino-ethyl)-3-{2-[3-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-1-phenyl-ureido]-ethyl}-ureido)-3-methyl-butyric acid methyl ester

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