1-(2-bromo-4-ethoxycarbonylphenyl)-3-methyl-3-phenyltriazene

Base Information

• Chemical Name: 1-(2-bromo-4-ethoxycarbonylphenyl)-3-methyl-3-phenyltriazene
• CAS No.: 1295605-36-5
• Molecular Formula: C₁₆H₁₆BrN₃O₂
• Molecular Weight: 362.226
• Mol file: 1295605-36-5.mol

Synonyms:1-(2-bromo-4-ethoxycarbonylphenyl)-3-methyl-3-phenyltriazene

Chemical Property of 1-(2-bromo-4-ethoxycarbonylphenyl)-3-methyl-3-phenyltriazene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-bromo-4-ethoxycarbonylphenyl)-3-methyl-3-phenyltriazene

There total 2 articles about 1-(2-bromo-4-ethoxycarbonylphenyl)-3-methyl-3-phenyltriazene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 3-bromo-4-aminobenzoate (7149-03-3) + N-methylaniline (100-61-8) → 1-(2-bromo-4-ethoxycarbonylphenyl)-3-methyl-3-phenyltriazene (1295605-36-5)

Guidance literature:

ethyl 3-bromo-4-aminobenzoate; With hydrogenchloride; In acetonitrile; at -10 - 20 ℃; for 0.25h;

With sodium nitrite; In acetonitrile; for 0.5h; Cooling;

N-methylaniline; With potassium carbonate; In water; acetonitrile; at -10 - 20 ℃; for 0.5h;

DOI:10.1021/ja2007438

Reference yield:

p-aminoethylbenzoate (94-09-7) → 1-(2-bromo-4-ethoxycarbonylphenyl)-3-methyl-3-phenyltriazene (1295605-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / chloroform / 20 °C

2.1: hydrogenchloride / acetonitrile / 0.25 h / -10 - 20 °C

2.2: 0.5 h / Cooling

2.3: 0.5 h / -10 - 20 °C

With hydrogenchloride; N-Bromosuccinimide; In chloroform; acetonitrile;

DOI:10.1021/ja2007438

Reference yield: 92.0%

1-(2-bromo-4-ethoxycarbonylphenyl)-3-methyl-3-phenyltriazene (1295605-36-5) → 1-(4-ethoxycarbonylphenyl)-1H-benzo[d][1,2,3]triazole

Guidance literature:

With [bis(acetoxy)iodo]benzene; potassium acetate; In N,N-dimethyl-formamide; at 120 ℃; for 72h; Reagent/catalyst; Temperature; Time; regioselective reaction; Catalytic behavior; Inert atmosphere;

DOI:10.1021/jo5009838

upstream raw materials:

ethyl 3-bromo-4-aminobenzoate

N-methylaniline

p-aminoethylbenzoate