(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl benzoate

Base Information

Chemical Name:(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl benzoate
CAS No.:1201946-65-7
Molecular Formula:C₂₃H₂₀ClNO₄S
Molecular Weight:441.935
Hs Code.:

Synonyms:(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl benzoate

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Chemical Property of (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl benzoate

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Technology Process of (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl benzoate

There total 4 articles about (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1147350-75-1,109904-27-0
2-Oxoclopidogrel

: 93-97-0
benzoic acid anhydride

: 1201946-65-7
(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl benzoate

Guidance literature:: With triethylamine; In acetonitrile; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm300038c

Reference yield:

: 32345-59-8
methyl (R)-2-chloromandelate

: 1201946-65-7
(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 4 h / 0 °C

2: potassium hydrogencarbonate / acetonitrile / 26 h / 20 °C / Inert atmosphere

3: triethylamine / acetonitrile / 2 h / 0 - 20 °C

With dmap; potassium hydrogencarbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm300038c

Reference yield:

: 10421-85-9,52923-23-6,52950-19-3,52950-18-2
(R)-2-chloromandelic acid

: 1201946-65-7
(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 2 h / Reflux

2: triethylamine / dmap / dichloromethane / 0 °C

3: potassium hydrogencarbonate / acetonitrile / 26 h / 20 °C / Inert atmosphere

4: triethylamine / acetonitrile / 2 h / 0 - 20 °C

With potassium hydrogencarbonate; triethylamine; dmap; sulfuric acid; In dichloromethane; acetonitrile;