Delcosine

Base Information

• Chemical Name: Delcosine
• CAS No.: 545-56-2
• Molecular Formula: C24H39NO7
• Molecular Weight: 453.57
• Mol file: 545-56-2.mol

Synonyms:Iliensine;Aconitane-1,7,8,14-tetrol,20-ethyl-6,16- dimethoxy-4-(methoxymethyl)-,(1R,6a,14R,- 16a)-;Delphamine;Lucaconine;

Chemical Property of Delcosine

Chemical Property:

• Vapor Pressure: 1.32E-16mmHg at 25°C
• Melting Point: 203-204°
• Refractive Index: 1.619
• Boiling Point: 594.4°C at 760 mmHg
• Flash Point: 313.3°C
• PSA: 111.85000
• Density: 1.37g/cm³
• LogP: -0.44520

Purity/Quality:

99% ^*data from raw suppliers

DELCOSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: The empirical formula of this alkaloid should read C26H41 N0 7
• Uses: Glycosidal dyestuff.

Technology Process of Delcosine

There total 7 articles about Delcosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

C26H39NO8 → delcosine (545-56-2,6835-87-6,1356-55-4,22091-01-6,56596-01-1,7097-12-3) + 1-epi-delcosine (1356-55-4,22091-01-6,56596-01-1,7097-12-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1248/cpb.48.660

Reference yield:

deltatsine (92631-66-8) → delcosine (545-56-2,6835-87-6,1356-55-4,22091-01-6,56596-01-1,7097-12-3)

Guidance literature:

With sulfuric acid; at 100 ℃; for 5h;

Reference yield:

14-O-acetyldelcosine (50676-21-6) → delcosine (545-56-2,6835-87-6,1356-55-4,22091-01-6,56596-01-1,7097-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / pyridinium dichromate / CH₂Cl₂ / 5 h / 0 °C

2: 36 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With lithium aluminium tetrahydride; dipyridinium dichromate; In tetrahydrofuran; dichloromethane; 1: Oxidation / 2: Reduction;

DOI:10.1248/cpb.48.660

upstream raw materials:

deltatsine

14-dehydrodelcosine

14-O-acetyldelcosine

Downstream raw materials:

14-dehydrodelcosine

14-O-acetyldelcosine

delsoline

14-benzoyldelcosine

Refernces

• 1、 Joshi, Balawant S.,Glinski, Jan A.,Chokshi, Hitesh P.,Chen, Szu-ying,Srivastava, Santosh K.,Pelletier, S. William. "DELTATSINE, A NEW C19-DITERPENOID ALKALOID FROM DELPHINIUM TATSIENENSE FRANCH". . p. 2037 - 2042. Retrieved 2007/10/02.