4-methylsulfonamidophenacyl 4-methylphenylacetate

Base Information

• Chemical Name: 4-methylsulfonamidophenacyl 4-methylphenylacetate
• CAS No.: 919122-34-2
• Molecular Formula: C₁₈H₁₉NO₅S
• Molecular Weight: 361.419
• Mol file: 919122-34-2.mol

Synonyms:4-methylsulfonamidophenacyl 4-methylphenylacetate

Chemical Property of 4-methylsulfonamidophenacyl 4-methylphenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methylsulfonamidophenacyl 4-methylphenylacetate

There total 2 articles about 4-methylsulfonamidophenacyl 4-methylphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-(methylsulfonylamino)acetophenone (5317-89-5) → 4-methylsulfonamidophenacyl 4-methylphenylacetate (919122-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / bromine; AlCl₃ / CHCl₃ / 0.5 h / 0 °C

2: 82 percent / triethylamine / acetonitrile / 1 h / 25 °C

With aluminium trichloride; bromine; triethylamine; In chloroform; acetonitrile;

DOI:10.1016/j.bmc.2006.10.023

Reference yield:

p-aminobenzophenone (99-92-3) → 4-methylsulfonamidophenacyl 4-methylphenylacetate (919122-34-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂ / 3 h / 25 °C

2: 81 percent / bromine; AlCl₃ / CHCl₃ / 0.5 h / 0 °C

3: 82 percent / triethylamine / acetonitrile / 1 h / 25 °C

With aluminium trichloride; bromine; triethylamine; In dichloromethane; chloroform; acetonitrile;

DOI:10.1016/j.bmc.2006.10.023

Reference yield: 42.0%

4-methylsulfonamidophenacyl 4-methylphenylacetate (919122-34-2) → N-[4-(5-oxo-4-p-tolyl-2,5-dihydro-furan-3-yl)-phenyl]-methanesulfonamide

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 25 ℃; for 4h;

DOI:10.1016/j.bmc.2006.10.023

upstream raw materials:

4'-(methylsulfonylamino)acetophenone

p-aminobenzophenone