1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate
CAS No.:1204535-09-0
Molecular Formula:C₁₆H₂₁F₃N₂O₄S
Molecular Weight:394.415
Hs Code.:

Synonyms:1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

There total 1 articles about 1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2991-42-6
4-trifluorophenylsulfonyl chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1204535-09-0
1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 1204535-09-0
1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

: 793679-07-9
1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine

Guidance literature:: 1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate; With hydrogenchloride; water; In 1,4-dioxane;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 1204535-09-0
1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

: 1291141-97-3
1-benzo[b]thiophen-3-yl-3-[4-(4-trifluoromethylbenzenesulfonyl)piperazin-1-yl]-ol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; acetic acid / water / 2 h / 20 °C

2: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

3: sodium tetrahydroborate / methanol / 1.5 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm2000773