ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate

Base Information

Chemical Name:ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate
CAS No.:351386-33-9
Molecular Formula:C₂₃H₃₆O₄Si
Molecular Weight:404.622
Hs Code.:

Synonyms:ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate

Suppliers and Price of ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate

There total 6 articles about ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 351386-46-4
isopropyl (2S)-2-benzyloxy-5-methyl-4-[(-2-tetrahydropyranyloxy)methyl]-4-hexenoate

: 351386-33-9
ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hexamethyldisilazane; BuLi / hexane; tetrahydrofuran / 0.17 h / -70 °C

1.2: TMEDA / hexane; tetrahydrofuran / 0.67 h

2.1: tBuOK / tetrahydrofuran / 0.05 h / 20 °C

2.2: 51 percent / tetrahydrofuran / 0.33 h / 20 °C

3.1: 61 percent / Ni(acac)2 / diethyl ether / 2 h / 20 °C

4.1: 84 percent / pyridinium tosylate; EtOH / 24 h / 50 °C

With bis(acetylacetonate)nickel(II); n-butyllithium; ethanol; potassium tert-butylate; pyridinium p-toluenesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1039/b010101j

Reference yield:

: 351386-44-2
isopropyl (2S)-2-hydroxy-5-methyl-4-[(2-tetrahydropyranyloxy)methyl]-4-hexenoate

: 351386-33-9
ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 89 percent / tBuOK; Bu₄NI / tetrahydrofuran / 0.5 h / 20 °C

2.1: hexamethyldisilazane; BuLi / hexane; tetrahydrofuran / 0.17 h / -70 °C

2.2: TMEDA / hexane; tetrahydrofuran / 0.67 h

3.1: tBuOK / tetrahydrofuran / 0.05 h / 20 °C

3.2: 51 percent / tetrahydrofuran / 0.33 h / 20 °C

4.1: 61 percent / Ni(acac)2 / diethyl ether / 2 h / 20 °C

5.1: 84 percent / pyridinium tosylate; EtOH / 24 h / 50 °C

With bis(acetylacetonate)nickel(II); n-butyllithium; ethanol; potassium tert-butylate; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1039/b010101j

Reference yield:

: 351386-50-0
ethyl (4S)-(2Z)-4-benzyloxy-3-(diethylphosphoryl)-7-methyl-6-[(2-tetrahydropyranyloxy)methyl]-2,6-octadienoate

: 351386-33-9
ethyl (2Z,4S)-4-benzyloxy-6-hydroxymethyl-7-methyl-3-[(trimethylsilyl)methyl]octa-2,6-dienoate

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / Ni(acac)2 / diethyl ether / 2 h / 20 °C

2: 84 percent / pyridinium tosylate; EtOH / 24 h / 50 °C

With bis(acetylacetonate)nickel(II); ethanol; pyridinium p-toluenesulfonate; In diethyl ether;
DOI:10.1039/b010101j