Technology Process of 8-(benzyloxy)-6,7-dimethoxy-3,4-dihydroisoquinoline
There total 6 articles about 8-(benzyloxy)-6,7-dimethoxy-3,4-dihydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C23H27NO6;
With
lithium triethylborohydride;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
DOI:10.1016/j.tet.2016.05.009
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; diphenyl phosphoryl azide / toluene / 1.5 h / 90 °C
2.1: boron trifluoride diethyl etherate / toluene / 20 h / 0 - 20 °C / Inert atmosphere
2.2: 1 h / 50 °C / pH 10
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C
3.2: 20 h / -78 - 20 °C
4.1: potassium carbonate / toluene / 20 h / 120 °C
5.1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C
5.2: 1 h / 0 - 20 °C
With
n-butyllithium; diphenyl phosphoryl azide; boron trifluoride diethyl etherate; lithium triethylborohydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1016/j.tet.2016.05.009
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron trifluoride diethyl etherate / toluene / 20 h / 0 - 20 °C / Inert atmosphere
1.2: 1 h / 50 °C / pH 10
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C
2.2: 20 h / -78 - 20 °C
3.1: potassium carbonate / toluene / 20 h / 120 °C
4.1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C
4.2: 1 h / 0 - 20 °C
With
n-butyllithium; boron trifluoride diethyl etherate; lithium triethylborohydride; potassium carbonate;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1016/j.tet.2016.05.009
