2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Base Information

Chemical Name:2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
CAS No.:1356009-99-8
Molecular Formula:C₂₇H₂₆ClF₂N₇O₃
Molecular Weight:569.998
Hs Code.:

Synonyms:2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

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Chemical Property of 2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

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Technology Process of 2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

There total 11 articles about 2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.8%

: 1263869-63-1
2,4-dichloro-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

: 1356009-48-7
5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-amine

: 1356009-99-8
2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 179412-96-5
tert-butyl (4-hydroxy-1-methylbutyl)carbamate

: 1356009-99-8
2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 18 h / 20 °C / Cooling with ice

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

With carbon tetrabromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1009-36-5
2-chloro-5-nitroanisole

: 1356009-99-8
2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1: boron tribromide / dichloromethane / -78 - 4 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 18 h / 20 °C

3: potassium hydroxide / dimethyl sulfoxide / 18 h / 95 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

With boron tribromide; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;