5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile

Base Information

Chemical Name:5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile
CAS No.:1202368-38-4
Molecular Formula:C₃₀H₂₄N₂O₄
Molecular Weight:476.532
Hs Code.:

Synonyms:5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile

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Chemical Property of 5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile

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Technology Process of 5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile

There total 12 articles about 5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 854371-80-5
2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-quinoline

: 1202376-88-2
5-(3-bromo-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile

: 1202368-38-4
5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; toluene; for 2h; Inert atmosphere; Reflux;

Reference yield:

: 17869-77-1
3-methyl-3-(trimethylsiloxy)-1-butyne

: 1202368-38-4
5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C

2.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

3.1: diethylamine / ethanol / 20 °C

4.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene / 2 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; n-butyllithium; caesium carbonate; toluene-4-sulfonic acid; diethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform; water; toluene;

Reference yield:

: 1202376-84-8
3-cyano-N,4-dimethoxy-N-methylbenzamide

: 1202368-38-4
5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C

2.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

3.1: diethylamine / ethanol / 20 °C

4.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene / 2 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; n-butyllithium; caesium carbonate; toluene-4-sulfonic acid; diethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform; water; toluene;