17869-77-1

Basic information

• Product Name: 3-METHYL-3-TRIMETHYLSILYLOXY-1-BUTYNE
• Synonyms: 1,1-DIMETHYLPROPYNYLOXYTRIMETHYLSILANE;[(1,1-DIMETHYL-2-PROPYNYL)OXY]TRIMETHYLSILANE;3-METHYL-3-TRIMETHYLSILYLOXY-1-BUTYNE;3-methyl-3-trimethylsiloxy-1-butyne;3-METHYL-3-TRIMETHYLSILYLOXY-1-BUTY;Silane,[(1,1-dimethyl-2-propynyl)oxy]trimethyl-;(1,1-Dimethyl-2-propynyl)(trimethylsilyl) ether;3-(Trimethylsiloxy)-3-methyl-1-butyne
• CAS NO: 17869-77-1
• Molecular Formula: C₈H₁₆OSi
• Molecular Weight: 156.3
• EINECS: 241-823-7
• Product Categories: Alkynes;Organic Building Blocks;Terminal;Building Blocks;Chemical Synthesis;Organic Building Blocks
• Mol File: 17869-77-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 115-116 °C(lit.)
• Flash Point: 30 °F
• Appearance: /Liquid
• Density: 0.806 g/mL at 25 °C(lit.)
• Vapor Pressure: 10mmHg at 25°C
• Refractive Index: n20/D 1.404(lit.)
• CAS DataBase Reference: 3-METHYL-3-TRIMETHYLSILYLOXY-1-BUTYNE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-3-TRIMETHYLSILYLOXY-1-BUTYNE(17869-77-1)
• EPA Substance Registry System: 3-METHYL-3-TRIMETHYLSILYLOXY-1-BUTYNE(17869-77-1)

Safety Data

• Hazard Codes: F
• Statements: 11
• Safety Statements: 16-36
• RIDADR: UN 1993 3/PG 2
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 17869-77-1(Hazardous Substances Data)

Usage

General Description

[(1,1-Dimethyl-2-propynyl)oxy]trimethylsilane is also known as trimethyl[(2-methyl-3-butyn-2-yl)oxy]silane. Its enthalpy of vaporization at boiling point has been reported.

InChI:InChI=1/C8H16OSi/c1-7-8(2,3)9-10(4,5)6/h1H,2-6H3

Upstream product

• 115-19-5 2-methyl-but-3-yn-2-ol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 75-77-4 chloro-trimethyl-silane 
• 1067-31-8 (1,1-dimethyl-prop-2-ynyloxy)-triethyl-stannane 

Downstream Products

• 1207611-52-6 C₂₈H₄₂O₃Si₂ 
• 301698-93-1 1-{4-(methylthio)phenyl}-4-hydroxy-4-methyl-2-pentyn-1-ol 
• 111277-09-9 5-(p-chlorophenyl)-2,2-dimethyl-3(2H)-furanone 
• 1202368-38-4 5-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)-2-methoxybenzonitrile 
• 1202368-47-5 4-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)benzonitrile 
• 1202368-54-4 5-(4-chlorophenyl)-2,2-dimethyl-4-(4-(quinolin-2-ylmethoxy)phenyl)furan-3(2H)-one 
• 1202375-46-9 4-(4-((6-fluoroquinolin-2-yl)methoxy)phenyl)-2,2-dimethyl-5-(pyridin-4-yl)furan-3(2H)-one 
• 1202368-23-7 2,2-dimethyl-5-(pyridin-4-yl)-4-(4-(quinolin-2-ylmethoxy)phenyl)furan-3(2H)-one 
• 1202368-85-1 2,2-dimethyl-4-(4-(quinolin-2-ylmethoxy)phenyl)-5-(thiazol-4-yl)furan-3(2H)-one 
• 1202375-45-8 4-(4-((3,5-dimethylpyridin-2-yl)methoxy)phenyl)-2,2-dimethyl-5-(pyridin-4-yl)furan-3(2H)-one 
• 1202375-44-7 2,2-dimethyl-4-(4-((5-methylpyridin-2-yl)methoxy)phenyl)-5-(pyridin-4-yl)furan-3(2H)-one 
• 1202376-87-1 5-(5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-2-methoxy benzonitrile 
• 1202376-74-6 4-(3-bromo-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzonitrile 
• 1202376-70-2 4-bromo-5-(4-chlorophenyl)-2,2-dimethylfuran-3(2H)-one 

Relevant articles and documents

A SHORT SYNTHESIS OF THE ANTIMITOTIC ALLYLIC DIEPOXIDE FUNCTIONAL ARRAY OF SPATOL

An α-lithio epoxide intermediate provides a highly stereocontrolled synthesis of the spatol allylic diepoxide, a functional array that is uniquely effective at inhibiting mitosis.

SN2′ boron-mediated Mitsunobu reactions - A new one-pot three-component synthesis of substituted enamides and enol benzoates

The conversion of (3-hydroxy-1-propen-1-yl)boronates to substituted enamides and enol benzoates is readily achieved in a one-pot procedure consisting of a regiocontrolled Mitsunobu reaction with convenient nucleophiles, followed by allylboration of aldehydes. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.

Universal method for trimethylsilylation of acetylenic alcohols and glycols

A highly convenient universal method for trimethylsilylation of acetylenic alcohols and glycols via treatment by hexamethyldisilazane in the presence of benzoic acid sulphimide as a catalyst has been developed. The rate of trimethylsilylation of acetylenic alcohols is reduced from primary to secondary and to tertiary alcohols accordingly, as well as with the decreasing of hydroxyl nucleophylicity. The toxicity of trimethylsilyl acetylenic ethers, except 2-trimethylsiloxy-3-butyne, is much lower than that of original compounds.