(2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one

Base Information

Chemical Name:(2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one
CAS No.:206191-90-4
Molecular Formula:C₂₂H₃₀OS
Molecular Weight:342.546
Hs Code.:

Synonyms:(2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one

Suppliers and Price of (2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one

There total 13 articles about (2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 206191-89-1
(2aR,3aR,6S,6aS,7aS)-6-Isopropyl-3a-methyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one

: 74-88-4
methyl iodide

: 206191-90-4
(2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; 1.) r.t., 1 h, 2.) r.t., 30 min;
DOI:10.1055/s-1998-5921

Reference yield:

: 106-72-9
2,6-dimethyl-5-hepten-1-al

: 206191-90-4
(2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one

Guidance literature:: Multi-step reaction with 13 steps

2: 73 percent / EtAlCl₂ / CH₂Cl₂; hexane / 4 h / Ambient temperature

3: 34 percent / BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

4: 95 percent / toluene / 0.75 h / Heating

5: 95 percent / LiAlH₄ / diethyl ether / 1.5 h

6: DEAD, Ph₃P / diethyl ether / 0.5 h

7: aq. KOH / methanol / 12 h / Ambient temperature

8: 97 percent / H₂ / norbornadiene (1,4-bisdiphenylphosphinobutane)rhodium(I) tetrafluoroborate / tetrahydrofuran / 4 h / 46543.3 Torr / Ambient temperature

9: 88 percent / Burgess reagent / benzene / 80 °C

10: 74 percent / Zn-Cu / diethyl ether / 2 h / Ambient temperature

11: 85 percent / Zn-Cu, NH₄Cl / methanol / 1.) r.t., 1 h, 2.) reflux, 1 h

12: 73 percent / hexamethyldisilazane, Me₃SiI / pentane / 1.) r.t., overnight, 2.) r.t., 30 min

13: 86 percent / LDA / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., 30 min

With potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; Burgess Reagent; trimethylsilyl iodide; hydrogen; ethylaluminum dichloride; copper; ammonium chloride; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; zinc; lithium diisopropyl amide; diethylazodicarboxylate; [(bicyclo[2.2.1]hepta-2,5-diene)(1,4-bis(diphenylphosphino)butane)rhodium(I)] tetrafluoroborate; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; toluene; pentane; benzene;
DOI:10.1055/s-1998-5921

Reference yield:

: 206191-77-7
(3S,7aR)-3-isopropyl-7a-methyl-2,3,7,7a-tetrahydro-1H-inden-5(6H)-one

: 206191-90-4
(2R,2aR,3aR,6S,6aS,7aS)-6-Isopropyl-2,3a-dimethyl-7a-phenylsulfanyl-decahydro-cyclobuta[f]inden-1-one

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / LiAlH₄ / diethyl ether / 1.5 h

2: DEAD, Ph₃P / diethyl ether / 0.5 h

3: aq. KOH / methanol / 12 h / Ambient temperature

4: 97 percent / H₂ / norbornadiene (1,4-bisdiphenylphosphinobutane)rhodium(I) tetrafluoroborate / tetrahydrofuran / 4 h / 46543.3 Torr / Ambient temperature

5: 88 percent / Burgess reagent / benzene / 80 °C

6: 74 percent / Zn-Cu / diethyl ether / 2 h / Ambient temperature

7: 85 percent / Zn-Cu, NH₄Cl / methanol / 1.) r.t., 1 h, 2.) reflux, 1 h

8: 73 percent / hexamethyldisilazane, Me₃SiI / pentane / 1.) r.t., overnight, 2.) r.t., 30 min

9: 86 percent / LDA / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., 30 min

With potassium hydroxide; lithium aluminium tetrahydride; Burgess Reagent; trimethylsilyl iodide; hydrogen; copper; ammonium chloride; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; zinc; lithium diisopropyl amide; diethylazodicarboxylate; [(bicyclo[2.2.1]hepta-2,5-diene)(1,4-bis(diphenylphosphino)butane)rhodium(I)] tetrafluoroborate; In tetrahydrofuran; methanol; diethyl ether; pentane; benzene;
DOI:10.1055/s-1998-5921