2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)ethan-1-ol

Base Information

Chemical Name:2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)ethan-1-ol
CAS No.:1606975-06-7
Molecular Formula:C₂₀H₁₉ClN₄O
Molecular Weight:366.85
Hs Code.:

Synonyms:2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)ethan-1-ol

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Chemical Property of 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)ethan-1-ol

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Technology Process of 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)ethan-1-ol

There total 6 articles about 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1606975-05-6
2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetic acid

: 1606975-06-7
2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)ethan-1-ol

Guidance literature:: 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetic acid; With dimethylsulfide borane complex; In tetrahydrofuran; at 55 ℃; for 1h;

With methanol; In tetrahydrofuran;

Reference yield:

: 25412-62-8
3-chlorobenzimidamide

: 1606975-06-7
2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)ethan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / ethanol / 20 h / 0 °C / Reflux

2.1: trichlorophosphate / 1.5 h / 0 - 100 °C

3.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere; Microwave irradiation

4.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1.5 h / 50 °C

4.2: pH Ca_. 4

5.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / 55 °C

With lithium hydroxide monohydrate; dimethylsulfide borane complex; water; sodium methylate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 24922-02-9
Ethyl 3-cyclopropyl-3-oxopropionate

: 1606975-06-7
2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)ethan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / ethanol / 20 h / 0 °C / Reflux

2.1: trichlorophosphate / 1.5 h / 0 - 100 °C

3.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere; Microwave irradiation

4.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1.5 h / 50 °C

4.2: pH Ca_. 4

5.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / 55 °C

With lithium hydroxide monohydrate; dimethylsulfide borane complex; water; sodium methylate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol;