tert-butyl (4-(3-cyanoquinoxaline-6-carbonyl)-3-fluorophenyl)carbamate

Base Information

Chemical Name:tert-butyl (4-(3-cyanoquinoxaline-6-carbonyl)-3-fluorophenyl)carbamate
CAS No.:1609932-74-2
Molecular Formula:C₂₁H₁₇FN₄O₃
Molecular Weight:392.389
Hs Code.:

Synonyms:tert-butyl (4-(3-cyanoquinoxaline-6-carbonyl)-3-fluorophenyl)carbamate

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Chemical Property of tert-butyl (4-(3-cyanoquinoxaline-6-carbonyl)-3-fluorophenyl)carbamate

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Technology Process of tert-butyl (4-(3-cyanoquinoxaline-6-carbonyl)-3-fluorophenyl)carbamate

There total 6 articles about tert-butyl (4-(3-cyanoquinoxaline-6-carbonyl)-3-fluorophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 201230-82-2
carbon monoxide

: 1415960-56-3
(4-((tert-butoxycarbonyl)amino)-2-fluorophenyl)boronic acid

: 1609932-73-1
7-bromoquinoxaline-2-carbaldehyde

: 1609932-74-2
tert-butyl (4-(3-cyanoquinoxaline-6-carbonyl)-3-fluorophenyl)carbamate

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; palladium diacetate; catacxium A; In toluene; at 97 ℃; Inert atmosphere;

Reference yield:

: 1196-57-2
quinoxalin-2⁽¹⁾-one

: 1609932-74-2
tert-butyl (4-(3-cyanoquinoxaline-6-carbonyl)-3-fluorophenyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: bromine / acetic acid / 20 °C

2: trichlorophosphate; N,N-dimethyl-formamide / 2 h / 120 °C

3: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

4: osmium(VIII) oxide; sodium periodate / tetrahydrofuran; water / 4.5 h / 0 - 20 °C

5: ammonium hydroxide; iodine / tetrahydrofuran / 2 h / 20 °C

6: palladium diacetate; N,N,N,N,-tetramethylethylenediamine; catacxium A / toluene / 97 °C / Inert atmosphere

With sodium periodate; osmium(VIII) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N,N,N,-tetramethylethylenediamine; bromine; iodine; palladium diacetate; ammonium hydroxide; triethylamine; N,N-dimethyl-formamide; catacxium A; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; water; acetic acid; toluene;

Reference yield:

: 82031-32-1
7-bromo-1H-quinoxalin-2-one

: 1609932-74-2
tert-butyl (4-(3-cyanoquinoxaline-6-carbonyl)-3-fluorophenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate; N,N-dimethyl-formamide / 2 h / 120 °C

2: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

3: osmium(VIII) oxide; sodium periodate / tetrahydrofuran; water / 4.5 h / 0 - 20 °C

4: ammonium hydroxide; iodine / tetrahydrofuran / 2 h / 20 °C

5: palladium diacetate; N,N,N,N,-tetramethylethylenediamine; catacxium A / toluene / 97 °C / Inert atmosphere

With sodium periodate; osmium(VIII) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N,N,N,-tetramethylethylenediamine; iodine; palladium diacetate; ammonium hydroxide; triethylamine; N,N-dimethyl-formamide; catacxium A; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; water; toluene;