(Z)-5-(1-(4-(trifluorometyl)phenyl)hex-3-en-1-yn-3-yl)benzo[d][1,3]dioxole

Base Information

• Chemical Name: (Z)-5-(1-(4-(trifluorometyl)phenyl)hex-3-en-1-yn-3-yl)benzo[d][1,3]dioxole
• CAS No.: 1301163-48-3
• Molecular Formula: C₂₀H₁₅F₃O₂
• Molecular Weight: 344.333
• Mol file: 1301163-48-3.mol

Synonyms:(Z)-5-(1-(4-(trifluorometyl)phenyl)hex-3-en-1-yn-3-yl)benzo[d][1,3]dioxole

Chemical Property of (Z)-5-(1-(4-(trifluorometyl)phenyl)hex-3-en-1-yn-3-yl)benzo[d][1,3]dioxole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-5-(1-(4-(trifluorometyl)phenyl)hex-3-en-1-yn-3-yl)benzo[d][1,3]dioxole

There total 2 articles about (Z)-5-(1-(4-(trifluorometyl)phenyl)hex-3-en-1-yn-3-yl)benzo[d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N'-(1-(benzo[d][1,3]dioxol-5-yl)butylidene)-4-methylbenzenesulfonohydrazide (1220985-67-0) + 4-trifluoromethylphenylacetylene (705-31-7) → (Z)-5-(1-(4-(trifluorometyl)phenyl)hex-3-en-1-yn-3-yl)benzo[d][1,3]dioxole (1301163-48-3)

Guidance literature:

With trifuran-2-yl-phosphane; palladium diacetate; p-benzoquinone; lithium tert-butoxide; In 1,4-dioxane; at 90 ℃; for 4h; stereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201007224

Reference yield:

1-(2H-benzo[3,4-d]1,3-dioxolen-5-yl)butan-1-one (63740-97-6) → (Z)-5-(1-(4-(trifluorometyl)phenyl)hex-3-en-1-yn-3-yl)benzo[d][1,3]dioxole (1301163-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.08 h / 20 °C / Inert atmosphere

2: trifuran-2-yl-phosphane; palladium diacetate; p-benzoquinone; lithium tert-butoxide / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

With trifuran-2-yl-phosphane; palladium diacetate; p-benzoquinone; lithium tert-butoxide; In 1,4-dioxane; methanol;

DOI:10.1002/anie.201007224

upstream raw materials:

N'-(1-(benzo[d][1,3]dioxol-5-yl)butylidene)-4-methylbenzenesulfonohydrazide

4-trifluoromethylphenylacetylene

1-(2H-benzo[3,4-d]1,3-dioxolen-5-yl)butan-1-one