4,4-dimethyl-6-(morpholine-4-sulfonyl)-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline

Base Information

Chemical Name:4,4-dimethyl-6-(morpholine-4-sulfonyl)-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline
CAS No.:1391609-00-9
Molecular Formula:C₂₅H₃₃N₃O₄S
Molecular Weight:471.621
Hs Code.:

Synonyms:4,4-dimethyl-6-(morpholine-4-sulfonyl)-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline

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Chemical Property of 4,4-dimethyl-6-(morpholine-4-sulfonyl)-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline

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Technology Process of 4,4-dimethyl-6-(morpholine-4-sulfonyl)-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline

There total 4 articles about 4,4-dimethyl-6-(morpholine-4-sulfonyl)-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 110-91-8,99108-56-2
morpholine

: 1391609-01-0
2-(3-bromo-phenyl)-4,4-dimethyl-6-(morpholine-4-sulfonyl)-1,2,3,4-tetrahydro-quinoline

: 1391609-00-9
4,4-dimethyl-6-(morpholine-4-sulfonyl)-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline

Guidance literature:: With copper(l) iodide; N,N-dimethylglycine hydrochoride; potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 16h;

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1391609-00-9
4,4-dimethyl-6-(morpholine-4-sulfonyl)-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2.1: ammonium chloride; iron / ethanol; water / 3 h / Reflux

2.2: pH 9

3.1: ytterbium(III) triflate / acetonitrile / 18 h / 80 °C / sealed tube

4.1: potassium carbonate; copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

With copper(l) iodide; N,N-dimethylglycine hydrochoride; iron; potassium carbonate; ammonium chloride; triethylamine; ytterbium(III) triflate; In ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 21626-70-0
4-(morpholinosulfonyl)aniline

: 1391609-00-9
4,4-dimethyl-6-(morpholine-4-sulfonyl)-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: ytterbium(III) triflate / acetonitrile / 18 h / 80 °C / sealed tube

2: potassium carbonate; copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

With copper(l) iodide; N,N-dimethylglycine hydrochoride; potassium carbonate; ytterbium(III) triflate; In dimethyl sulfoxide; acetonitrile;