ethyl cis-<2-(N-benzoyl-N-benzylamino)cyclopentyl>acetate

Base Information

• Chemical Name: ethyl cis-<2-(N-benzoyl-N-benzylamino)cyclopentyl>acetate
• CAS No.: 124461-33-2
• Molecular Formula: C₂₃H₂₇NO₃
• Molecular Weight: 365.472
• Mol file: 124461-33-2.mol

Synonyms:ethyl cis-<2-(N-benzoyl-N-benzylamino)cyclopentyl>acetate

Chemical Property of ethyl cis-<2-(N-benzoyl-N-benzylamino)cyclopentyl>acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl cis-<2-(N-benzoyl-N-benzylamino)cyclopentyl>acetate

There total 26 articles about ethyl cis-<2-(N-benzoyl-N-benzylamino)cyclopentyl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

N-<(E)-6-ethoxycarbonylhex-5-enyl>-N-(2-iodobenzyl)benzamide (157099-93-9) → ethyl cis-<2-(N-benzoyl-N-benzylamino)cyclopentyl>acetate (124461-33-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 8h; Heating;

Reference yield: 38.0%

N-benzyl-N<(E)-ethoxycarbonylhex-5-enyl>-2-iodobenzamide (124461-15-0) → ethyl cis-<2-(N-benzoyl-N-benzylamino)cyclopentyl>acetate (124461-33-2)

Guidance literature:

With tri-n-butyl-tin hydride; In benzene; at 80 ℃;

DOI:10.1021/ja00158a075

Reference yield:

hex-5-en-1-amine (34825-70-2) → ethyl cis-<2-(N-benzoyl-N-benzylamino)cyclopentyl>acetate (124461-33-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / aq. NaOH / tetrahydrofuran / 12 h

2: 85 percent / NaOH, K₂CO₃, tetrabutylammonium hydrogen sulfate / benzene / 4 h / Heating

3: ozone / CH₂Cl₂; methanol / -78 °C

4: NaH / tetrahydrofuran / 5 h

5: 51 percent / Bu₃SnH, AIBN / benzene / 8 h / Heating

With sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; potassium carbonate; ozone; In tetrahydrofuran; methanol; dichloromethane; benzene;

upstream raw materials:

ethanol

N-benzyl-N<(E)-ethoxycarbonylhex-5-enyl>-2-iodobenzamide

N-<(E)-6-ethoxycarbonylhex-5-enyl>-N-(2-iodobenzyl)benzamide

Cyclopentene oxide