2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one

Base Information

• Chemical Name: 2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one
• CAS No.: 1380091-10-0
• Molecular Formula: C₂₃H₁₆ClN₅OS
• Molecular Weight: 445.932
• Mol file: 1380091-10-0.mol

Synonyms:2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one

Chemical Property of 2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one

There total 6 articles about 2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-azido-4-chlorobenzene (3296-05-7) + 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one (18741-24-7) + propargyl bromide (106-96-7) → 2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one (1380091-10-0)

Guidance literature:

With sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper diacetate; potassium carbonate; In ethanol; water; at 80 ℃; for 8h;

DOI:10.1080/00397911.2011.558968

Reference yield: 83.0%

1-azido-4-chlorobenzene (3296-05-7) + 3-phenyl-2-(prop-2-yn-1-ylthio)quinazolin-4(3H)-one (53954-28-2) → 2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one (1380091-10-0)

Guidance literature:

With copper(ll) sulfate pentahydrate; ascorbic acid; In water; N,N-dimethyl-formamide; Reflux;

DOI:10.1016/j.ejmech.2017.12.065

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-3-phenylquinazolin-4(3H)-one (1380091-10-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

3: copper(ll) sulfate pentahydrate; ascorbic acid / N,N-dimethyl-formamide; water / Reflux

With copper(ll) sulfate pentahydrate; potassium carbonate; potassium hydroxide; ascorbic acid; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2017.12.065

upstream raw materials:

1-azido-4-chlorobenzene

3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

propargyl bromide

2-mercapto-3-phenyl-3H-quinazolin-4-one