[3-((4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)phenyl]methanesulfonamide

Base Information

Chemical Name:[3-((4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)phenyl]methanesulfonamide
CAS No.:1395493-47-6
Molecular Formula:C₁₉H₁₈FN₃O₃S
Molecular Weight:387.435
Hs Code.:

Synonyms:[3-((4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)phenyl]methanesulfonamide

Suppliers and Price of [3-((4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)phenyl]methanesulfonamide

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Chemical Property of [3-((4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)phenyl]methanesulfonamide

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Technology Process of [3-((4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)phenyl]methanesulfonamide

There total 2 articles about [3-((4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1333468-54-4
2-chloro-4-(4-fluoro-2-methoxyphenyl)pyridine

: 344750-15-8
(3-aminophenyl)methanesulfonamide

: 1395493-47-6
[3-((4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)phenyl]methanesulfonamide

Guidance literature:: With sodium t-butanolate; palladium chloride*2MeCN; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 110 ℃; for 18h; Inert atmosphere;

Reference yield:

: 73583-37-6
2-chloro-4-bromopyridine

: 179899-07-1
4-fluoro-2-methoxyphenylboronic acid

: 1395493-47-6
[3-((4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 145 °C / microwave irradiation; Inert atmosphere

2: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium chloride*2MeCN / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere

With potassium phosphate; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium chloride*2MeCN; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; N,N-dimethyl-formamide;