1,1-dimethylethyl [6-chloro-5-(2-oxoethyl)-4-pyrimidinyl][2-fluoro-4-(methylsulfonyl)phenyl]carbamate

Base Information

Chemical Name:1,1-dimethylethyl [6-chloro-5-(2-oxoethyl)-4-pyrimidinyl][2-fluoro-4-(methylsulfonyl)phenyl]carbamate
CAS No.:1001398-37-3
Molecular Formula:C₁₈H₁₉ClFN₃O₅S
Molecular Weight:443.883
Hs Code.:

Synonyms:1,1-dimethylethyl [6-chloro-5-(2-oxoethyl)-4-pyrimidinyl][2-fluoro-4-(methylsulfonyl)phenyl]carbamate

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Chemical Property of 1,1-dimethylethyl [6-chloro-5-(2-oxoethyl)-4-pyrimidinyl][2-fluoro-4-(methylsulfonyl)phenyl]carbamate

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Technology Process of 1,1-dimethylethyl [6-chloro-5-(2-oxoethyl)-4-pyrimidinyl][2-fluoro-4-(methylsulfonyl)phenyl]carbamate

There total 4 articles about 1,1-dimethylethyl [6-chloro-5-(2-oxoethyl)-4-pyrimidinyl][2-fluoro-4-(methylsulfonyl)phenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1001397-14-3
6-chloro-N-[2-fluoro-4-(methylsulfonyl)phenyl]-5-(2-propen-1-yl)-4-pyrimidinamine

: 24424-99-5
di-tert-butyl dicarbonate

: 1001398-37-3
1,1-dimethylethyl [6-chloro-5-(2-oxoethyl)-4-pyrimidinyl][2-fluoro-4-(methylsulfonyl)phenyl]carbamate

Guidance literature:: With potassium osmate(VI) dihydrate; sodium periodate; In water; acetone; for 4h;
DOI:10.1021/jm301404a

Reference yield: 100.0%

: 1001398-37-3
1,1-dimethylethyl [6-chloro-5-(2-oxoethyl)-4-pyrimidinyl][2-fluoro-4-(methylsulfonyl)phenyl]carbamate

Guidance literature:

Reference yield:

: 16019-30-0
6-hydroxy-5-(2-propen-1-yl)-4(1H)-pyrimidinone

: 1001398-37-3
1,1-dimethylethyl [6-chloro-5-(2-oxoethyl)-4-pyrimidinyl][2-fluoro-4-(methylsulfonyl)phenyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 4 h / Inert atmosphere; Reflux

2: sodium hydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3: potassium osmate(VI) dihydrate; sodium periodate / water; acetone / 4 h

With potassium osmate(VI) dihydrate; sodium periodate; sodium hydride; trichlorophosphate; In tetrahydrofuran; water; acetone;
DOI:10.1021/jm301404a