(E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Base Information

Chemical Name:(E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid
CAS No.:1430561-32-2
Molecular Formula:C₃₈H₃₂ClN₇O₅
Molecular Weight:702.169
Hs Code.:

(E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Synonyms:(E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

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Chemical Property of (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

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Technology Process of (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

There total 8 articles about (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₂H₄₀ClN₇O₅

: 1430561-32-2
(E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 477721-50-9
tert-butyl 4-formamidobenzoate

: 1430561-32-2
(E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; trichlorophosphate / tetrahydrofuran / 24 h / 0 - 20 °C

2: ethanol / 24 h / Reflux

3: trifluoroacetic acid / dichloromethane

With triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; 2: |Ugi Condensation;

Reference yield:

: 18144-47-3
tert-butyl 4-aminobenzoate

: 1430561-32-2
(E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(6-methyl-1,2,3,4-tetrahydroquinoline-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 4-methyl-morpholine / dichloromethane / 18 h / 0 °C

2: triethylamine; trichlorophosphate / tetrahydrofuran / 24 h / 0 - 20 °C

3: ethanol / 24 h / Reflux

4: trifluoroacetic acid / dichloromethane

With 4-methyl-morpholine; dmap; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; 3: |Ugi Condensation;